Pharmaceutical giant Pfizer’s 100% acquisition of Allergen PLC was the biggest M&A deal of 2015, according to a report by Thomson Reuters.

The deal between two US companies is worth $191.5bn and is one of 10 in the top 15 between two parties from the country. Others include Charter Communications’ acquisition of Time Warner Cable ($78.4bn) and The Dow Chemical Company’s agreement to buy DuPont ($68.4bn).

>See also: 2015 strongest year on record for M&A deals

British companies are involved in both the second and third biggest deals of the year. Belgian brewer Anheuser-Busch’s acquisition of SAB Miller ($120.8bn) was in second place while Royal Dutch Shell’s deal to buy BG Group ($81bn) was third.

Those deals were the only featured in the top 15 with any European parties. Apart from the UK, the only other countries featured are The UK, Belgium, the Netherlands, Israel, Canada and Hong Kong.

Top 15 M&A deals of 2015:

1 Pfizer’s acquisition of Allergen PLC – $191.5bn

2 Anheuser-Busch’s acquisition of SAB Miller – $120.8bn

3 Royal Dutch Shell’s acquisition of BG Group –$81bn

4 Charter Communications’ acquisition of Time Warner Cable – $78.4bn

5 The Dow Chemical’s acquisition of DuPont – $68.4bn

6 Dell Inc’s acquisition of EMC Corp – $65.8bn

7 Energy Transfer Equity’s acquisition of The Williams Cos – $55.9bn

8 HJ Heinz’s acquisition of Kraft Foods Group – $54.7bn

9 Anthem Inc’s acquisition of Cigna Corp – $49.4bn

10 Shareholders’ takeover of Paypal Holdings Inc – $46.8bn

11 Cheung Kong Holdings’ acquisition of Hutchison Whampoa – $45.4bn

12 Teva Pharmaceutical Industries’ acquisition of Allergen PLC-Generic Bus – $40.5bn

13 Canadian Pacific Railway’s acquisition of Norfolk Southern Corp – $36.6bn

14 Avago Technologies’ acquisition of Broadcom Corp – $36.5bn

15 Berkshire Hathaway Inc’s acquisition of Precision Castparts Corp – $35.8bn

Further reading:See also: UK M&A market hits eight-year high